CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
| Autor: | Neil Stahl, Steven H. Nye, Yanping Li, Susan J. Birren, Nancy Y. Ip, Tert G. Boulton, David J. Anderson, Tadamitus Kishimoto, Tetsuya Taga, Samuel Davis, Kiyoshi Yasukawa, George D. Yancopoulos |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Cellular differentiation Nerve Tissue Proteins Ciliary neurotrophic factor Leukemia Inhibitory Factor Models Biological General Biochemistry Genetics and Molecular Biology Cell Line Antigens CD Neurotrophic factors Internal medicine Cytokine Receptor gp130 medicine Animals Ciliary Neurotrophic Factor Leukemia Inhibitory Factor Receptor alpha Subunit Phosphorylation Receptors Immunologic Neurons Lymphokines Membrane Glycoproteins biology Interleukin-6 Cell Differentiation Glycoprotein 130 Receptors Interleukin-6 Growth Inhibitors Rats Cell biology Endocrinology biology.protein Tyrosine Ciliary neurotrophic factor receptor Signal transduction Leukemia inhibitory factor Cell Division Signal Transduction |
| Zdroj: | Cell. 69:1121-1132 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/0092-8674(92)90634-o |
| Popis: | Ciliary neurotrophic factor (CNTF) has a variety of actions within the nervous system. While some of the actions of leukemia inhibitory factor (LIF) on neurons resemble those of CNTF, LIF also has broad actions outside of the nervous system that in many cases mimic those of interleukin-6 (IL-6). Comparison of the tyrosine phosphorylations and gene activations induced by CNTF and LIF in neuron cell lines reveals that they are indistinguishable and also very similar to signaling events that characterize LIF and IL-6 responses in hematopoietic cells. We provide a basis for the overlapping actions of these three factors by demonstrating that the shared CNTF and LIF signaling pathways involve the IL-6 signal transducing receptor component gp130. Thus, the receptor system for CNTF is surprisingly unlike those used by the nerve growth factor family of neurotrophic factors, but is instead related to those used by a subclass of hematopoietic cytokines. |
| Databáze: | OpenAIRE |
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