Novel inflammatory cytokines (IL-36, 37, 38) in the aqueous humor from patients with chronic primary angle closure glaucoma
| Autor: | Thi Hoang Anh Nguyen, Jin-ling Zhang, Ya-ying Chen, Xiang-yuan Song, Shisan Bao, Yu-yan Zhang, Jing-yi Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine genetic structures Immunology Glaucoma Inflammation Aqueous humor Proinflammatory cytokine Aqueous Humor Pathogenesis Macular Degeneration 03 medical and health sciences 0302 clinical medicine Chronic primary angle closure glaucoma medicine Humans Immunology and Allergy Prospective Studies Vision Ocular Aged Aged 80 and over Pharmacology Arc (protein) business.industry Interleukins Middle Aged medicine.disease eye diseases 030104 developmental biology 030220 oncology & carcinogenesis Chronic Disease Optic nerve Female sense organs Inflammation Mediators medicine.symptom Glaucoma Angle-Closure business Interleukin-1 |
| Zdroj: | International Immunopharmacology. 71:164-168 |
| ISSN: | 1567-5769 |
| Popis: | Glaucoma eventually leads to optic nerve damage and vision loss without medical intervention. More than 50% of glaucoma caused blindness are attributed to primary angle closure glaucoma, particularly in Asians. It is reported that immune inflammation is involved in the progress of glaucoma. Increased inflammation cytokines are detected in the aqueous humor of chronic primary angle closure glaucoma (CPACG). IL-36, IL-37 and IL-38, are novel cytokines and are involved in many inflammatory diseases, including inflammatory bowel diseases and acute anterior uveitis, but the possible contributing role in the pathogenesis of CPACG is unclear. In our current study, increased IL-36, IL-37 and IL-38 were detected in the aqueous humor of CPACG compared with age-related cataract (ARC). Furthermore, a significant correlation was detected between mean deviation of visual field (MDVF) of CPACG and IL-36, IL-37 or IL-38, respectively. Our data suggest IL-36, IL-37 and IL-38 might contribute to the immunological mediated pathogenesis of CPACG, despite the eye being an immune-privileged organ under normal conditions. The precise underlying mechanism of these cytokines during the development of CPACG remains to be explored. Our findings may be useful in therapeutic targeting of specific pathology. |
| Databáze: | OpenAIRE |
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