Role of splanchnic and lumbar sympathetic nerves in physiologic responses to fever and hypoxia in dogs
| Autor: | E. A. Johnson, J. W. Geiger, W. G. Kubicek, W. F. Geber |
|---|---|
| Rok vydání: | 1959 |
| Předmět: |
Sympathetic nervous system
Sympathetic Nervous System Fever medicine.diagnostic_test business.industry Lumbosacral Region chemistry.chemical_element Hypoxia (medical) Hematocrit Oxygen Dogs Lumbar medicine.anatomical_structure chemistry Physiology (medical) Anesthesia medicine Animals Humans medicine.symptom Hypoxia business Splanchnic Oxygen content Blood ph |
| Zdroj: | American Journal of Physiology-Legacy Content. 196:685-690 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1959.196.3.685 |
| Popis: | Induced fever up to 42°C rectal temperature produced an increase in oxygen consumption rate, plasma creatinine, blood lactic acid, hematocrit, blood oxygen content, blood pH, pulse rate, a decrease in blood sugar and a fall in blood CO2 content. Hypoxia superimposed upon the fever tended to produce an increase in blood pressure, hematocrit and pulse rate. Hypoxia probably depressed cerebral cortical activity in the unanesthetized febrile dogs. The most important function of the splanchnic and lumbar sympathetic nerves was apparently the control of the circulatory system and secondly the partial regulation of blood glucose probably through liberation of epinephrine from the adrenal medulla. A reduction in heat tolerance of the animals was observed after sympathectomy. The effects of anesthesia were apparently a reduced sensitivity of the respiratory centers and chemoreceptors. When compared to the unanesthetized experience, lower values were observed for oxygen consumption rate, blood pH, blood oxygen content, hematocrit, plasma creatinine and blood lactic acid, and in higher values for pulse rate, blood pressure, blood CO2 content and blood glucose. |
| Databáze: | OpenAIRE |
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