Regulation of B Lymphocytes by Dendritic Cells
Autor: | Edward A. Clark |
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Jazyk: | angličtina |
Rok vydání: | 1997 |
Předmět: |
Immunology
Antigen presentation Palatine Tonsil Immunoglobulins chemical and pharmacologic phenomena Cell Communication Cell Fractionation Lymphocyte Activation Monocytes Cell Line 03 medical and health sciences Mice 0302 clinical medicine L Cells Commentaries Cell Adhesion Immunology and Allergy Cytotoxic T cell Animals Humans CD40 Antigens Antigen-presenting cell 030304 developmental biology 0303 health sciences B-Lymphocytes CD40 biology Follicular dendritic cells Chemistry Cell Differentiation Natural killer T cell Acquired immune system Fetal Blood Coculture Techniques 3. Good health Cell biology B-1 cell Langerhans Cells biology.protein Commentary Immunologic Memory 030215 immunology |
Zdroj: | The Journal of Experimental Medicine |
ISSN: | 1540-9538 0022-1007 |
Popis: | After antigen capture, dendritic cells (DC) migrate into T cell-rich areas of secondary lymphoid organs, where they induce T cell activation, that subsequently drives B cell activation. Here, we investigate whether DC, generated in vitro, can directly modulate B cell responses, using CD40L-transfected L cells as surrogate activated T cells. DC, through the production of soluble mediators, stimulated by 3- to 6-fold the proliferation and subsequent recovery of B cells. Furthermore, after CD40 ligation, DC enhanced by 30-300-fold the secretion of IgG and IgA by sIgD- B cells (essentially memory B cells). In the presence of DC, naive sIgD+ B cells produced, in response to interleukin-2, large amounts of IgM. Thus, in addition to activating naive T cells in the extrafollicular areas of secondary lymphoid organs, DC may directly modulate B cell growth and differentiation. |
Databáze: | OpenAIRE |
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