Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients
| Autor: | C. Andrew van Hasselt, Paul K.S. Chan, Kin-Wang To, Cheuk Lun Sham, Michael Chi Fai Tong, Dennis L.Y. Lee |
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| Rok vydání: | 2010 |
| Předmět: |
Cyclin-Dependent Kinase Inhibitor p21
Male Pathology medicine.medical_specialty Herpesvirus 4 Human Inverted papilloma medicine.disease_cause Turbinates Polymerase Chain Reaction Virus Cohort Studies Basal (phylogenetics) Nasal Polyps otorhinolaryngologic diseases medicine Prevalence Humans Nasal polyps Papillomaviridae In Situ Hybridization Retrospective Studies Papilloma Inverted business.industry medicine.disease Epstein–Barr virus Immunohistochemistry Gene Expression Regulation Neoplastic Tumor Virus Infections Otorhinolaryngology Immunology DNA Viral Papilloma Hong Kong Female Tumor Suppressor Protein p53 business Paranasal Sinus Neoplasms |
| Zdroj: | Headneck. 34(4) |
| ISSN: | 1097-0347 |
| Popis: | Background The purpose of this study of human papillomavirus (HPV), Epstein–Barr virus (EBV), p21, and p53 in sinonasal inverted papilloma (IP) was to help elucidate its pathogenesis. Methods Seventy-three IPs, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to HPV polymerase chain reaction (PCR) study. Seventy-three IPs, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to EBV in situ hybridization (ISH), p21, and p53 immunohistochemical (IHC) studies. Results HPV was positive in 3 of 73 IPs (4.1%). All specimens were EBV negative. In all, 99% of IPs showed strong and diffuse p21 nuclear reactivity. Most nasal polyps and hypertrophied turbinates showed weak to moderate immunoreactivity of the basal and parabasal cells. Only focal p53 immunoreactivity of the basal and parabasal cells was found in 19% of IPs and 40% of nasal polyps. Conclusions HPV prevalence of our IP is low. EBV is not present in IP. High p21 and low p53 expression in IP suggests a non–p53-dependent regulation pathway. © 2011 Wiley Periodicals, Inc. Head Neck, 2012 |
| Databáze: | OpenAIRE |
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