Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Annulation of Modified Enals with Enolizable Aldehydes

Autor:	Rajesh G. Gonnade, Trinadh Kaicharla, Akkattu T. Biju, Santhivardhana Reddy Yetra, Sunita S. Kunte
Rok vydání:	2013
Předmět:	chemistry.chemical_compound Annulation chemistry Organic Chemistry Enantioselective synthesis Organic chemistry Physical and Theoretical Chemistry Biochemistry Carbene Catalysis
Zdroj:	Organic Letters. 15:5202-5205
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol4026155
Popis:	N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the α,β-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303a9f7a17eda71facbc8556cd589eba https://doi.org/10.1021/ol4026155 Zobrazit plný text záznamu