Post-transplant lymphoproliferative disorders: a simplified overview
| Autor: | John K.C. Chan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Lymphoproliferative disorders
Transplantation Pathology medicine.medical_specialty Lymphoma business.industry medicine.medical_treatment Immunosuppression Hyperplasia medicine.disease Organ transplantation Lesion Nephrology Monoclonal Immunology medicine medicine.symptom business B-lymphocytes/pathology |
| Zdroj: | Hong Kong Journal of Nephrology. 3(2):57-66 |
| ISSN: | 1561-5413 |
| DOI: | 10.1016/s1561-5413(09)60060-0 |
| Popis: | Post-transplant lymphoproliferative disorders comprise a spectrum of reactive to neoplastic lymphoid proliferations that occur in organ transplant recipients as a result of the iatrogenic immuno-suppression. They usually appear within 1 year after the transplant, although they can sometimes occur after a long interval. Most cases are B-cell proliferations that are driven by Epstein-Barr virus, and the major types are 1. early lesions (plasmacytic hyperplasia and infectious mononucleosis-like lesion), which are usually polyclonal; 2. polymorphic post-transplant lymphoproliferative disorders, which are usually oligoclonal or monoclonal; and 3. monomorphic post-transplant lymphoproliferative disorders, which are morphologically identical to conventional lymphomas, are monoclonal, and commonly exhibit structural alterations in oncogenes and tumor-suppressor genes. Early lesions and a proportion of polymorphic post-transplant lymphoproliferative disorders regress with reduction in immunosuppressants, whereas almost all monomorphic post-transplant lymphoproliferative disorders progress and require lymphoma-type treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|