Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease
Autor: | Carlo Wilke, Frank Gillardon, Christian Deuschle, Evelyn Dubois, Markus A. Hobert, Jennifer Müller vom Hagen, Stefanie Krüger, Saskia Biskup, Cornelis Blauwendraat, Michael Hruscha, Stephan A. Kaeser, Peter Heutink, Walter Maetzler, Matthis Synofzik |
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Rok vydání: | 2015 |
Předmět: |
Male
genetics [Alzheimer Disease] cerebrospinal fluid [Intercellular Signaling Peptides and Proteins] Progranulins Alzheimer Disease Humans ddc:610 genetics [Frontotemporal Dementia] Aged blood [Biomarkers] metabolism [Amyotrophic Lateral Sclerosis] genetics [Intercellular Signaling Peptides and Proteins] blood [Intercellular Signaling Peptides and Proteins] Amyotrophic Lateral Sclerosis Middle Aged genetics [Amyotrophic Lateral Sclerosis] Neurology cerebrospinal fluid [Biomarkers] Frontotemporal Dementia metabolism [Frontotemporal Dementia] GRN protein human Intercellular Signaling Peptides and Proteins Female Neurology (clinical) metabolism [Alzheimer Disease] Biomarkers |
Zdroj: | Current Alzheimer research 13(6), 654-662 (2016). doi:10.2174/1567205013666160314151247 |
ISSN: | 1875-5828 |
DOI: | 10.2174/1567205013666160314151247 |
Popis: | Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics. |
Databáze: | OpenAIRE |
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