Male breast cancer: clinical features and multimodal treatment in a retrospective survey analysis at Italian centers

Autor: La Verde, Nicla, Collova, Elena, Sara Lonardi, Generali, Daniele, Moretti, Anna, Atzori, Francesco, Cazzaniga, Marina, Saggia, Chiara, Tondulli, Luca, Marcon, Ilaria, Gentile, Anna Lisa, Rossello, Rosalba, Martelli, Olga, Aglione, Stefania, Farina, Gabriella, Cinquini, Michela, Garassino, Marina
Přispěvatelé: La Verde, Nicla, Collovà, Elena, Lonardi, Sara, Generali, Daniele, Moretti, Anna, Atzori, Francesco, Cazzaniga, Marina, Saggia, Chiara, Tondulli, Luca, Marcon, Ilaria, Gentile, Anna Lisa, Rossello, Rosalba, Martelli, Olga, Aglione, Stefania, Farina, Gabriella, Cinquini, Michela, Garassino, Marina
Rok vydání: 2013
Předmět:
Male
Cancer Research
Receptor
ErbB-2
Systemic treatment
Triple Negative Breast Neoplasms
Kaplan-Meier Estimate
Medical Records
0302 clinical medicine
ErbB-2
Retrospective Studie
Recurrence
Risk Factors
Receptors
Antineoplastic Combined Chemotherapy Protocols
030212 general & internal medicine
Adjuvant
Progesterone
Mastectomy
Tumor
Early breast cancer
General Medicine
Middle Aged
Treatment Outcome
Oncology
Italy
Receptors
Estrogen
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Receptors
Progesterone
Human
Receptor
Adult
Antineoplastic Agents
Hormonal
Triple Negative Breast Neoplasm
Antineoplastic Agents
Breast Neoplasms
Adjuvant therapy
Risk Assessment
Disease-Free Survival
Breast Neoplasms
Male
03 medical and health sciences
Biomarkers
Tumor
Chemotherapy
Humans
Systemic treatments
Aged
Neoplasm Staging
Retrospective Studies
Antineoplastic Combined Chemotherapy Protocol
Hormonal
Radiotherapy
Risk Factor
Estrogen
Male breast cancer
Radiotherapy
Adjuvant
Medical Record
Biomarkers
Zdroj: ResearcherID
ISSN: 2038-2529
Popis: Aims and background We report a collection of data about early breast cancer in male patients from 13 Italian institutions. Methods and study design We obtained data from patient charts and performed statistical analysis. The primary end points were overall survival and disease-free survival. Results A total of 205 men with invasive breast cancer was identified, with a median age of 66 years. Pathological characteristics were heterogeneous for T stage, N stage and HER2 status. Histological subtype was predominantly ductal infiltrating carcinoma. Most of them were hormone receptor positive. Mastectomy was the most common strategy. Postsurgical treatment was not standardized. Patients with large tumors were more likely to be treated with chemotherapy. Disease recurrence was associated with an ER+ and PR+ status. Conclusions We identified a correlation between relapse and hormone receptor expression, as is the case in female breast cancer.
Databáze: OpenAIRE
Externí odkaz: