Nimotuzumab in combination with radiotherapy in high grade glioma patients
| Autor: | Jose Alert, Maria Teresa Solomon, Nederlay Miranda, Eugenia Jorrín, Ivonne Chon, Jorge Juan Marinello, Patricia Lorenzo-Luaces, Tania Crombet |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Population Antineoplastic Agents Astrocytoma Antibodies Monoclonal Humanized Disease-Free Survival Young Adult Internal medicine Glioma medicine Humans Nimotuzumab Epidermal growth factor receptor education Aged Pharmacology education.field_of_study biology Brain Neoplasms Cumulative dose business.industry Middle Aged medicine.disease Combined Modality Therapy Surgery Radiation therapy Clinical Study biology.protein Molecular Medicine Female Neoplasm Grading Glioblastoma business medicine.drug Anaplastic astrocytoma |
| Zdroj: | Cancer Biology & Therapy. 15:504-509 |
| ISSN: | 1555-8576 1538-4047 |
| DOI: | 10.4161/cbt.28021 |
| Popis: | Nimotuzumab, a humanized antibody targeting epidermal growth factor receptor, has potent anti-proliferative, anti-angiogenic, and pro-apoptotic effects in vitro and in vivo. It also reduces the number of radio-resistant CD133(+) glioma stem cells. The antibody has been extensively evaluated in patients with advanced head and neck, glioma, lung, esophageal, pancreatic, and gastric cancer. In this single institution experience, 35 patients with anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) were treated with irradiation and 200 mg doses of nimotuzumab. The first 6 doses were administered weekly, together with radiotherapy, and then treatment continued every 21 days until 1 year. The median number of doses was 12, and the median cumulative dose was thus 2400 mg of nimotuzumab. The most frequent treatment-related toxicities were increase in liver function tests, fever, nausea, anorexia, asthenia, dizziness, and tremors. These adverse reactions were classified as mild and moderate. The median survival time was 12.4 mo or 27.0 mo for patients with GBM or AA patients, respectively, who received curative-intent radiotherapy in combination with the antibody. The survival time of a matched population treated at the same hospital with irradiation alone was decreased (median 8.0 and 12.2 mo for GBM and AA patients, respectively) compared with that of the patients who received nimotuzumab and curative-intent radiotherapy. We have thus confirmed that nimotuzumab is a very well-tolerated drug, lacking cumulative toxicity after maintenance doses. This study, in a poor prognosis population, validates the previous data of survival gain after combining nimotuzumab and radiotherapy, in newly diagnosed high-grade glioma patients. |
| Databáze: | OpenAIRE |
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