Prevalence and factors associated with HIV-1 multi-drug resistance over the past two decades in the Italian ARCA database
| Autor: | Lombardi, F, Giacomelli, A, Armenia, D, Lai, A, Dusina, A, Bezenchek, A, Timelli, L, Saladini, F, Vichi, F, Corsi, P, Colao, G, Bruzzone, B, Gagliardini, R, Callegaro, A, Castagna, A, Santoro, Mm, ARCA Study, Group. |
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| Přispěvatelé: | Lombardi, Francesca, Giacomelli, Andrea, Armenia, Daniele, Lai, Alessia, Dusina, Alex, Bezenchek, Antonia, Timelli, Laura, Saladini, Francesco, Vichi, Francesca, Corsi, Paola, Colao, Grazia, Bruzzone, Bianca, Gagliardini, Roberta, Callegaro, Annapaola, Castagna, Antonella, Santoro, Maria Mercedes |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Enfuvirtide Drug Resistance HIV Infections Drug resistance medicine.disease_cause computer.software_genre Settore MED/07 chemistry.chemical_compound 0302 clinical medicine Risk Factors Antiretroviral Therapy Highly Active Pharmacology (medical) 030212 general & internal medicine Viral Database Coinfection virus diseases General Medicine Hepatitis B Infectious Diseases Italy Reverse Transcriptase Inhibitors Female Multiple Cohort study medicine.drug Microbiology (medical) Adult Genotyping Anti-HIV Agents Hepatitis C virus 030106 microbiology Antiretroviral Therapy Lower risk Settore MED/17 - MALATTIE INFETTIVE 03 medical and health sciences Drug Resistance Multiple Viral medicine HIV-1 Multi-drug resistance Cumulative genotypic resistance test Acquired drug resistance Humans Highly Active HIV Integrase Inhibitors Maraviroc Retrospective Studies Hepatitis B virus business.industry Retrospective cohort study HIV Protease Inhibitors CD4 Lymphocyte Count chemistry business computer |
| Popis: | Despite successful antiretroviral therapy (ART), patients infected with human immunodeficiency virus (HIV) can develop multi-class drug resistance (MDR). This retrospective study aimed to explore the prevalence of HIV-1 drug resistance over the past two decades by focusing on HIV-MDR and its predictors. ART-experienced patients with HIV with results from at least one plasma genotypic resistance test (GRT) from 1998 to 2018, from the Antiviral Response Cohort Analysis database, were included in this study. The temporal trend of resistance to any drug class was evaluated by considering all GRTs. Prevalence and predictors of HIV-MDR were analysed by consideration of cumulative GRTs. Among 15 628 isolates from 6802 patients, resistance to at least one drug class decreased sharply from 1998 to 2010 (1998-2001: 78%; 2008-2010: 59%; P |
| Databáze: | OpenAIRE |
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