The production and properties of gel precipitated aluminium hydroxide spheres containing imipramine
| Autor: | E S Lane, G G Shaw, JM Newton, D C Sammon, M P Ramsey |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pharmacology
Active ingredient Imipramine Hot Temperature Chemistry Precipitation (chemistry) Aluminium hydroxide Drug release rate Inorganic chemistry Pharmaceutical Science Hydrochloric acid Aluminum Hydroxide Dosage form chemistry.chemical_compound medicine Chemical Precipitation SPHERES Gels medicine.drug Nuclear chemistry |
| Zdroj: | The Journal of pharmacy and pharmacology. 36(1) |
| ISSN: | 0022-3573 |
| Popis: | The production of aluminium hydroxide spheres containing imipramine by gel precipitation of liquid feed solutions has been described. Washing and heating procedures applied to the precipitated spheres markedly affected the rate of drug release from the spheres into 0·1m hydrochloric acid. Increasing the imipramine content of the spheres also altered the drug release rate. The effects described have been explained with reference to model theories of the precipitation and ageing of aluminium hydroxide gels in the presence and absence of ‘foreign’ anions. |
| Databáze: | OpenAIRE |
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