Effects of piracetam on indices of cognitive function in a delayed alternation task in young and aged rats
| Autor: | Antoine Lenègre, Roger D. Porsolt, Sylvain Roux, Daniel Milinkevitch, Isabelle Hubert |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Aging medicine.medical_specialty Clinical Biochemistry Short-term memory Audiology Toxicology Biochemistry Developmental psychology Behavioral Neuroscience Cognition Animal model Reaction Time medicine Animals Rats Wistar Biological Psychiatry Pharmacology Delayed alternation Dose-Response Relationship Drug Piracetam Rats Memory Short-Term Conditioning Operant Psychology medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 49:683-688 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(94)90088-4 |
| Popis: | The effects of piracetam (64, 128, and 256 mg/kg PO) on the performance of a delayed alternation in a Skinner Box were investigated. Test sessions consisted of 36 trials during which animals were first presented with a single lever (left or right) followed 5, 10, or 20 s later by two levers. A press on the lever opposite to that presented previosly (nonmatching to sample) was rewarded. The number of correct responses and the reaction times to the one- and two-lever presentations were recorded. All animals received all treatments in a balanced order. Aged animals showed clear deficits on all three parameters. Piracetam was without effect on the performance of young animals but dose-dependently decreased the choice reaction times (two levers) in aged animals without affecting the other two parameters. These results suggest that piracetam does not affect short-term memory but may facilitate choice behavior in aged animals. |
| Databáze: | OpenAIRE |
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