Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India
| Autor: | Pradip K. Ghoshal, Bhubaneswar Halder, Arup Dasbiswas, Kajal Ganguly, Nripendranath Mandal, Santanu Biswas |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Apolipoprotein B Coronary Artery Disease Bioinformatics Gastroenterology Coronary artery disease Tertiary Care Centers Genotype Odds Ratio Medicine CAD Allele frequency biology Incidence Gene polymorphism Middle Aged Apolipoprotein Female Original Article lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine medicine.medical_specialty RD1-811 India Risk Assessment Apolipoproteins E Internal medicine Confidence Intervals Humans Diseases of the circulatory (Cardiovascular) system Genetic Predisposition to Disease Alleles Aged Apolipoproteins B Polymorphism Genetic Apolipoprotein A-I business.industry Case-control study Odds ratio medicine.disease Survival Analysis Radiography Case-Control Studies RC666-701 Multivariate Analysis biology.protein Surgery business |
| Zdroj: | Indian Heart Journal, Vol 65, Iss 6, Pp 658-665 (2013) |
| ISSN: | 0019-4832 |
| Popis: | Aim: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). Methods: We determined distribution of MspI apo AI, EcoRI apo B, HhaI apo E gene polymorphisms, plasma apolipoproteins and lipids levels among 150 patients having CAD admitted to the Department of Cardiology, N.R.S. Medical College & Hospital, Kolkata, India during June 2010–June 2012 and 150 age sex matched healthy controls. Results: We found that ApoAI concentration of studied population was significantly different in each genotypes of −75 G/A apo AI (p |
| Databáze: | OpenAIRE |
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