Enhancing fMRI contrast in awake-behaving primates using intravascular magnetite dextran nanopartieles
| Autor: | Kyle A. Bernheim, William G. Bradley, Dar-Yeong Chen, Richard A. Andersen, David J. Dubowitz |
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| Rok vydání: | 2001 |
| Předmět: |
Male
genetic structures Photic Stimulation Iron Central nervous system Contrast Media Blood volume Macaque chemistry.chemical_compound biology.animal medicine Animals Visual Cortex Behavior Animal biology business.industry General Neuroscience Dextrans Oxides Awareness Neurophysiology Macaca mulatta Magnetic Resonance Imaging Ferrosoferric Oxide medicine.anatomical_structure Dextran Visual cortex chemistry Cerebral cortex Cerebrovascular Circulation business Neuroscience Biomedical engineering |
| Zdroj: | Neuroreport. 12:2335-2340 |
| ISSN: | 0959-4965 |
| Popis: | Functional MRI in awake-behaving primates is an emerging tool for bridging the gap between human fMRI and neurophysiology information from nonhuman primates. We report the use of magnetite dextran nanoparticles (Feridex) as a blood-pool agent to enhance fMRI contrast-to-noise (CNR) in primate FMRI. The intravascular half-life of the magnetite dextran was long compared to lanthanide chelates (T1=2a 198 min) with shortened T2 relaxation observed in blood and cerebral cortex. Greater than 3-fold enhancement in the percentage MR signal change was observed using nanoparticles (13%) compared with conventional BOLD fMRI (4%). The calculated regional cerebral blood volume in macaque primary visual cortex increased 32% with photic stimulation. The increased CNR allows greater flexibility in the design of awake-behaving primate fMRI studies with the potential for improvements in resolution and significantly shortened imaging times. NeuroReport 12:2335‐2340 & 2001 Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
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