Clinicopathological study of a hilar nodule in the livers of long-term survivors with biliary atresia
| Autor: | Noriko Aida, Masato Shinkai, Toshiji Nishi, Fukuo Kondo, Keisuke Kato, Yokatsu Ohama, Kazuaki Misugi, Yukichi Tanaka, Rieko Ijiri |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Liver Cirrhosis
Male Pathology medicine.medical_specialty medicine.medical_treatment Portoenterostomy Hepatic Liver transplantation Pathology and Forensic Medicine Lesion Postoperative Complications Biliary atresia Biliary Atresia Proliferating Cell Nuclear Antigen medicine Humans Fluorescent Antibody Technique Indirect Porta hepatis biology business.industry Infant Nodule (medicine) Histology General Medicine medicine.disease Proliferating cell nuclear antigen medicine.anatomical_structure Liver Focal Nodular Hyperplasia biology.protein Immunohistochemistry Female Radiology medicine.symptom business Tomography X-Ray Computed |
| Zdroj: | Pathology international. 51(1) |
| ISSN: | 1320-5463 |
| Popis: | With the application of liver transplantation for patients with biliary atresia (BA), we have had the opportunity to review the clinicopathologic features of the native livers from 10 transplanted BA patients. A single large nodule at porta hepatis (hilar nodule) was noted in three of 10 patients, and an ill-defined nodule-like lesion at porta hepatis was present in two other patients. The three BA patients with hilar nodules were long-term survivors, compared to the patients with nodule-like and those without nodules. The hilar nodules measured between 5.0 cm and 8.0 cm and histologically, they were partly surrounded by fibrous septa with relatively well-preserved liver architectures and fewer inflammatory cells at the portal triads when compared to the surrounding cirrhotic lesions. No nuclear or cellular atypia was observed. Proliferating cell nuclear antigen labeling index was higher in the surrounding cirrhotic lesions than the hilar nodules. The nodule-like lesions at porta hepatis also showed similar light microscopic and immunohistochemical features as the hilar nodules. These hilar nodules did not seem to contain any malignant potential. The benign histology with relatively well-preserved liver architecture and the preferential site of occurrence at porta hepatis where bile seemed to flow more smoothly, suggested possible residues of less-affected hepatic tissues. |
| Databáze: | OpenAIRE |
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