A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014–2018)
| Autor: | Patrícia Brasil, Bianca F Branco, André Ricardo Ribas Freitas, Adrienne Guignard, Eliana Nogueira Castro de Barros, Ana Claudia Machado Duarte, Guilherme S. Ribeiro, Francisco Hideo Aoki, Melanie de Boer, Brigitte Cheuvart, Ariane de Jesus Lopes de Abreu, Maria Paula Gomes Mourão, Maria Beatriz Borges, Kleber Giovanni Luz, Eduardo Oliveira, Tatiana Guimarães de Noronha, Guilherme Amaral Calvet, Daniele Fernandes de Aguiar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Adolescent Epidemiology 030106 microbiology Seroprevalence Infectious and parasitic diseases RC109-216 Serology Dengue fever Cohort Studies Dengue 03 medical and health sciences Young Adult 0302 clinical medicine Seroepidemiologic Studies Internal medicine Clinical endpoint Medicine Humans 030212 general & internal medicine Prospective Studies Child Asymptomatic Infections Brazil (max 6) Dengue vaccine Family Characteristics business.industry Incidence (epidemiology) Incidence General Medicine Dengue Virus Middle Aged medicine.disease Multicentre cohort study Infectious Diseases Child Preschool Female business Brazil Cohort study |
| Zdroj: | International Journal of Infectious Diseases, Vol 108, Iss, Pp 443-453 (2021) |
| ISSN: | 1201-9712 |
| Popis: | Objectives To estimate the incidence of dengue infection across geographically distinct areas of Brazil. Methods This prospective, household-based, cohort study enrolled participants in five areas and followed them up for up to 4 years (2014–2018). Dengue seroprevalence was assessed at each scheduled visit. Suspected dengue cases were identified through enhanced passive and active surveillance. Acute symptomatic dengue infection was confirmed through reverse-transcriptase quantitative polymerase chain reaction in combination with an antigenic assay (non-structural protein 1) and serology. Results Among 3300 participants enrolled, baseline seroprevalence was 76.2%, although only 23.3% of participants reported a history of dengue. Of 1284 suspected symptomatic dengue cases detected, 50 (3.9%) were laboratory-confirmed. Based on 8166.5 person-years (PY) of follow-up, the incidence of laboratory-confirmed symptomatic infection (primary endpoint) was 6.1 per 1000 PY (95% confidence interval [CI]: 4.5, 8.1). Incidence varied substantially in different years (1.8–7.4 per 1000 PY). The incidence of inapparent primary dengue infection was substantially higher: 41.7 per 1000 PY (95% CI: 31.1, 54.6). Conclusions Our findings, highlighting that the incidence of dengue infection is underestimated in Brazil, will inform the design and implementation of future dengue vaccine trials. Clinical trial registration NCT01751139 |
| Databáze: | OpenAIRE |
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