Clinical significance of technetium-99m methylene diphosphonate myocardial uptake: association with carcinoma of the prostate
| Autor: | V. R. McCready, C Anagnostopoulos, T Heary, A. M. Al-Nahhas, W Hirsch, S Jinnouchi |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty chemistry.chemical_element Technetium Tc 99m Medronate Scintigraphy Technetium Asymptomatic Gastroenterology Bone and Bones Muscular Diseases Prostate Neoplasms Internal medicine medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Clinical significance Radionuclide Imaging Aged Aged 80 and over medicine.diagnostic_test business.industry Prostatic Neoplasms Heart General Medicine medicine.disease medicine.anatomical_structure Bone scintigraphy chemistry Case-Control Studies Female Bone Diseases medicine.symptom business Technetium-99m |
| Zdroj: | European Journal of Nuclear Medicine. 22:148-153 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/bf00838945 |
| Popis: | Benign myocardial uptake of technetium-99m labelled phosphates, not related to cardiac or metabolic disorders, has been documented except in the case of 99mTc-methylene diphosphonate (MDP). The aim of this study was to assess the frequency of myocardial uptake and its possible association with malignant tumours in general and prostatic carcinoma in particular. We reviewed bone scintigrams performed with either 99mTc-hydroxydiphosphonate (HDP) or 99mTc-MDP over a period of more than 2 years for all patients with prostatic carcinoma and a matching group of patients suffering from other malignant and non-malignant disorders. A total of 965 scintigrams of 812 patients (males = 559, females = 253; age range 50-91 years, average age 69.2 years) were reviewed. Increased myocardial uptake was detected in 19 scintigrams (MDP = 13, HDP = 6) of 18 patients (17 males, one female). Most of the male patients with increased myocardial uptake had prostatic carcinoma (13/17) and were over 80 years of age (12/17). All patients were free of any cardiac or noncardiac disorder that might account for such uptake. When scintigraphy was repeated in the same patient, the uptake of 99mTc-HDP was more diffuse and of higher grade than that of 99mTc-MDP. "Benign" myocardial uptake of 99mTc-MDP is more common than previously thought. Although uptake of radiophosphates is attributed to asymptomatic atherosclerotic changes associated with old age, a strong association with prostatic carcinoma exists which may indicate variations in the bone: soft tissue affinity of different MDP complexes. |
| Databáze: | OpenAIRE |
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