Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway

Autor: David G.S. Farmer, Davide Martelli, Michael J. McKinley, Robin M. McAllen, Virginia L. Brooks, Evilin Naname Komegae
Přispěvatelé: DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, Da definire, AREA MIN. 05 - Scienze biologiche, Komegae, Evilin Naname, Stephen Farmer, David George, Brooks, Virginia Leah, McKinley, Michael Joseph, McAllen, Robin Michael, Martelli, Davide
Rok vydání: 2018
Předmět:
Lipopolysaccharides
Male
0301 basic medicine
Sympathetic nervous system
medicine.medical_treatment
Efferent
Anti-Inflammatory Agents
Interleukin 10 (IL-10)
Lipopolysaccharide (LPS)
Stimulation
Systemic inflammation
Rats
Sprague-Dawley
Behavioral Neuroscience
0302 clinical medicine
Abdomen
Neural Pathways
Greater splanchnic nerve
Tumor necrosis factor α (TNF)
Interleukin-10
Splanchnic anti-inflammatory pathway
medicine.anatomical_structure
Cytokines
medicine.symptom
Splanchnic
Vagus nerve stimulation
medicine.medical_specialty
Immunology
Splanchnic nerves
Article
Vagus nerve
03 medical and health sciences
Internal medicine
medicine
Animals
Inflammation
Afferent Pathways
Tumor Necrosis Factor-alpha
Endocrine and Autonomic Systems
business.industry
Splanchnic Nerves
Endotoxemia
Rats
Disease Models
Animal
030104 developmental biology
Endocrinology
business
030217 neurology & neurosurgery
Zdroj: Brain, Behavior, and Immunity. 73:441-449
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2018.06.005
Popis: none 6 si Electrical stimulation of the vagus nerve (VNS) is a novel strategy used to treat inflammatory conditions. Therapeutic VNS activates both efferent and afferent fibers; however, the effects attributable to vagal afferent stimulation are unclear. Here, we tested if selective activation of afferent fibers in the abdominal vagus suppresses systemic inflammation. In urethane-anesthetized rats challenged with lipopolysaccharide (LPS, 60µg/kg, i.v.), abdominal afferent VNS (2 Hz for 20 mins) reduced plasma tumor necrosis factor alpha (TNF) levels 90 minutes later by 88% compared with unmanipulated animals. Pre-cutting the cervical vagi blocked this anti-inflammatory action. Interestingly, the surgical procedure to expose and prepare the abdominal vagus for afferent stimulation ('vagal manipulation') also had an anti-inflammatory action. Levels of the anti-inflammatory cytokine IL-10 were inversely related to those of TNF. Prior bilateral section of the splanchnic sympathetic nerves reversed the anti-inflammatory actions of afferent VNS and vagal manipulation. Sympathetic efferent activity in the splanchnic nerve was shown to respond reflexly to abdominal vagal afferent stimulation. These data demonstrate that experimentally activating abdominal vagal afferent fibers suppresses systemic inflammation, and that the efferent neural pathway for this action is in the splanchnic sympathetic nerves. mixed Komegae, Evilin Naname; Stephen Farmer, David George; Brooks, Virginia Leah; McKinley, Michael Joseph; McAllen, Robin Michael; Martelli, Davide Komegae, Evilin Naname; Stephen Farmer, David George; Brooks, Virginia Leah; McKinley, Michael Joseph; McAllen, Robin Michael; Martelli, Davide
Databáze: OpenAIRE
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