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SF1: Pimonidazole and carbonic anhydrase IX (CA-IX) staining patterns in 4T1 and MDA-MB-231 breast tumors; SF2: Breast tumor stained with hematoxylin & eosin (H&E), showing different stages of necrosis; SF3: Representative examples of the corresponding habitat maps from MRI and histology for the 4T1 and MDA-MB-231 tumor samples; SF4: Histograms showing the pixels values distribution of Area under the curve (AUC), slope and time to max (TTM) from DCE-MRI in each cluster of representative MRI habitat maps for 4T1 and MDA-MB-231 tumor samples; SF5: Representative examples showing that the DCE-MRI maps have visual similarity with pimonidazole staining in breast samples. SF6: Representative examples of MRI habitat maps, which were created by clustering five MRI-parameters [T2-map, T2*-map, Slope, Area under the curve (AUC) and time to max (TTM)] using a Gaussian Mixture Model (GMM) Expectation-Maximization algorithm. SF7: Comparison of mean values of each parameter from habitat maps generated by clustering five MRI-parameters [T2-map, T2*-map, Slope, Area under the curve (AUC) and time to max (TTM)]; SF8: Histograms showing the distribution of the Apparent diffusion coefficient (ADC) values in the cluster classified as non-viable tumor cells in the MRI habitat map. SF9: Representative images of the immunohistochemistry for perilipin-1 in breast tumor samples. |
