Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens
| Autor: | Rebecca A. Halpin, Leonardo J. Ferreyra, Nadia Fedorova, Jason Seto, Morris S. Jones, Shoaleh Dehghan, Regis P. Kowalski, K.L. Therese, Susmita Shrivastava, Ashrafali M. Ismail, Gurdeep Singh, Ramana Madupu, Jaya Rajaiya, Jambulingam Malathi, Donald Seto, Timothy B. Stockwell, Qiwei Zhang, Kalpana Dommaraju, Tiange Cui, Neha Gupta, Eric G. Romanowski, David W. Dyer, Adriana E. Kajon, Hajib Narahari Madhavan, James Chodosh, Albert Heim |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Genotype Epidemiology Immunology ved/biology.organism_classification_rank.species Population Genomics Genome Viral Biology Microbiology Genome Article DNA sequencing Adenovirus Infections Human Evolution Molecular 03 medical and health sciences Phylogenetics Molecular evolution Virology Drug Discovery Humans Typing Model organism education Phylogeny Recombination Genetic Genetics education.field_of_study Base Sequence ved/biology Adenoviruses Human Computational Biology Correction virus diseases Sequence Analysis DNA General Medicine eye diseases 3. Good health 030104 developmental biology Infectious Diseases DNA Viral Parasitology |
| Zdroj: | Emerging Microbes & Infections |
| ISSN: | 2222-1751 |
| Popis: | Human adenoviruses (HAdVs) are uniquely important "model organisms" as they have been used to elucidate fundamental biological processes, are recognized as complex pathogens, and are used as remedies for human health. As pathogens, HAdVs may effect asymptomatic or mild and severe symptomatic disease upon their infection of respiratory, ocular, gastrointestinal, and genitourinary systems. High-resolution genomic data have enhanced the understanding of HAdV epidemiology, with recombination recognized as an important and major pathway in the molecular evolution and genesis of emergent HAdV pathogens. To support this view and to actualize an algorithm for identifying, characterizing, and typing novel HAdVs, we determined the DNA sequence of 95 isolates from archives containing historically important pathogens and collections housing currently circulating strains to be sequenced. Of the 85 samples that were completely sequenced, 18 novel recombinants within species HAdV-B and D were identified. Two HAdV-D genomes were found to contain novel penton base and fiber genes with significant divergence from known molecular types. In this data set, we found additional isolates of HAdV-D53 and HAdV-D58, two novel genotypes recognized recently using genomics. This supports the thesis that novel HAdV genotypes are not limited to "one-time" appearances of the prototype but are of importance in HAdV epidemiology. These data underscore the significance of lateral genomic transfer in HAdV evolution and reinforce the potential public health impact of novel genotypes of HAdVs emerging in the population. |
| Databáze: | OpenAIRE |
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