Evaluation of seasonal variations of the structure and anti-inflammatory activity of sulfated polysaccharides extracted from the red alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae)
| Autor: | Inken Groth, Niels Grünewald, Susanne Alban |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Polymers and Plastics
medicine.drug_class Neutrophils Anti-Inflammatory Agents Hyaluronoglucosaminidase Bioengineering Sulfuric Acid Esters Anti-inflammatory Biomaterials Algae Polysaccharides Botany Materials Chemistry medicine Humans Enzyme Inhibitors biology Extraction (chemistry) Anticoagulants biology.organism_classification Molecular Weight Baltic sea Delesseriaceae Delesseria sanguinea Rhodophyta Ceramiales Sulfated polysaccharides Seasons Leukocyte Elastase |
| Zdroj: | Biomacromolecules. 10(5) |
| ISSN: | 1526-4602 |
| Popis: | Delesseria sanguinea (Hudson) Lamouroux was shown to contain sulfated polysaccharides (D.s.-SP) with anti-inflammatory effects. This red macroalga turned out to dominantly populate an artificial reef in the southwestern Baltic Sea. An important aspect for its economical utilization is to obtain D.s.-SP in a reproducible quality. The aim of the study was to evaluate the seasonal variability of D.s.-SP; for this, algae batches were harvested monthly over the period of one year. Structural and pharmacological characterization of the isolated D.s.-SP showed that an optimized and standardized aqueous extraction (85 degrees C) leads to reproducible products without any significant seasonal variations of their elastase and hyaluronidase inhibitory activities. Besides the yields (from 17.9% in April to 6.12% in September), only the glucose content of the D.s.-SP batches seasonally varied (April, 7.48% +/- 1.00%, September, 22.8% +/- 1.2%) due to certain coextraction of starch-like glucans. In principle, algae material can be harvested throughout the year, but the optimum harvesting time is in spring. |
| Databáze: | OpenAIRE |
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