Effects of gamma-interferon and FK506 on resting B cell proliferation of New Zealand black/white F1 mice
| Autor: | Masanori Funauchi, Atsushi Horiuchi, Yoshiki Tomioka, K Hamada, Sumihiko Higashitani, Masahide Minoda, Yasushi Yamazoe, Mitsuhiro Higashikawa, Hitoshi Sugishima, M Ohno |
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| Rok vydání: | 1992 |
| Předmět: |
Cytotoxicity
Immunologic Lipopolysaccharides medicine.medical_specialty medicine.medical_treatment Immunology Biology Lymphocyte Activation Microbiology Tacrolimus Interferon-gamma Mice Immune system Virology Internal medicine polycyclic compounds medicine Animals Lupus Erythematosus Systemic Interferon gamma B-Lymphocytes Mice Inbred BALB C Lupus erythematosus Mice Inbred NZB Cell growth Drug Synergism DNA medicine.disease Molecular biology In vitro Endocrinology Cytokine Polyclonal antibodies Humoral immunity biology.protein Hybridization Genetic Female Interleukin-4 medicine.drug |
| Zdroj: | Microbiology and immunology. 36(8) |
| ISSN: | 0385-5600 |
| Popis: | We examined the effects of gamma-interferon (gamma-IFN) and the new immunosuppressant FK506 on resting B cell proliferation of New Zealand black/white F1 hybrid (B/W F1) mice, an animal model of human systemic lupus erythematosus (SLE). gamma-IFN and FK506 inhibited in a dose-dependent manner both B cell proliferation and autoantibody production of resting B cells respectively. There was a synergistic interaction between gamma-IFN and FK506 in their inhibition and they did not exhibit cell cytotoxicity. This in vitro synergism of gamma-IFN and FK506 may have clinical application in that low doses of gamma-IFN and FK506 combinations may be effective to correct polyclonal B cell activation of patients with SLE. |
| Databáze: | OpenAIRE |
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