Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population

Autor: Soledad Montoro, María J. Jaras-Hernández, Pablo Racionero, Jesús Peña-López, Cristina Plaza, Javier Coca-Robinot, Gloria Amorena, María Valencia, Cristina García-Quero, Ricardo Romero-Martín, Carlos Lahoz, María Hernandez-Pérez, Lucía Martínez-Tobar, Rosa de Miguel, Alexa P. Benítez, Mar Lago, María L. Cachán, Francisca García-Iglesias, María San Basilio, Adriana de la Hoz-Polo, Clara Hernández-Blanco, Margarita Sánchez-Orgaz, Ana Boto de los Bueis, Marta Bautista-Barea, José M. Mostaza, Susana Rivas-Vila, Bárbara González-Ferrer, Mónica Martínez-Prieto, Eva Estirado, Pedro Fernández-Pérez, Victor Hontañón, Patricia Mir-Ihara, María Barcenilla, Alberto Luna, Celia García Torres, Talía Sainz-Costa, Miriam Romero, Francisco J. Blanco, Pablo Rodríguez-Merlos, María del Pino-Cidad, Isabel Villalaín, Javier Domínguez, Cosme Lavín-Dapena, Araceli Menéndez-Saldaña, Teresa González-Alegre, Isabel Mogollón, Almudena del Hierro-Zarzuelo, Aaron Zapata Negreiros, Marta Varas, María S. Montoro-Romero, Irene Hernández-Martín, Blanca Sánchez
Rok vydání: 2020
Předmět:
Zdroj: Archives of Gerontology and Geriatrics
ISSN: 1872-6976
Popis: Highlights • Older patients with COVID infection have a similar clinical course than younger subjects. • Males have a greater COVID mortality than females. • Worsening dyspnea and decline renal function during admission associate with death. • Treatment with RAAS inhibitors associates with a greater survival.
Introduction Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age. Patients and methods We studied 404 patients ≥ 75 years (mean age 85.2 ± 5.3 years, 55 % males), with PCR-confirmed COVID-19 infection, attended in two hospitals in Madrid (Spain). Patients were followed-up until they were discharged from the hospital or until death. Results Symptoms started 2–7 days before admission, and consisted of fever (64 %), cough (59 %), and dyspnea (57 %). A total of 145 patients (35.9 %) died a median of 9 days after hospitalization. In logistic regression analysis, predictive factors of death were age (OR 1.086; 1.015–1.161 per year, p = 0.016), heart rate (1.040; 1.018–1.061 per beat, p
Databáze: OpenAIRE
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