Low-grade squamous intraepithelial lesions among women with HIV
| Autor: | Eunice van den Berg, Cyril J. Van Gelderen, Yasmin Adam, Koena A. Kgomo, Anushka R. Lekha, Portia K. Manamela, Pamela Michelow |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Referral Cytodiagnosis Papanicolaou stain HIV Infections Cervical intraepithelial neoplasia South Africa Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Interquartile range Cytology Humans Medicine 030212 general & internal medicine Referral and Consultation Aged Retrospective Studies Vaginal Smears Colposcopy 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Obstetrics Papillomavirus Infections Obstetrics and Gynecology Histology General Medicine Odds ratio Middle Aged Uterine Cervical Dysplasia medicine.disease Cross-Sectional Studies Female Squamous Intraepithelial Lesions of the Cervix business |
| Zdroj: | International Journal of Gynecology & Obstetrics. 142:78-83 |
| ISSN: | 0020-7292 |
| DOI: | 10.1002/ijgo.12505 |
| Popis: | Objectives To assess whether women with HIV who had low-grade squamous intraepithelial lesions (LSIL) on cytology had cervical disease. Methods The present retrospective cross-sectional study included data from women with LSIL who attended a tertiary hospital in South Africa between April 1, 2003, and December 31, 2013. Patient information was extracted from a colposcopy database. Results The study included 652 patients. The median age was 36 years (interquartile range [IQR] 31-42 years; range 18-66 years) and the median parity was three (IQR 2-5; range 0-10). In all, 266 (40.8%) women had a histology result of HPV or cervical intraepithelial neoplasia 1 (CIN1); 386 (59.2%) had a histology result of CIN2 or higher. The median cluster of differentiation 4 (CD4) count was 275.00 cells/mm3 (IQR 173.50-434.00 cells/mm3 ; range 2-1211 cells/mm3 ). A total of 312 (47.9%) women were using antiretroviral therapy. Use of antiretroviral therapy (unadjusted odds ratio 0.57; P=0.001) and a CD4 count of at least 200 cells/mm3 (unadjusted odds ratio 0.81; P=0.002) were associated with a histology result of HPV or CIN1. Conclusion Most of the women with a cytology report of LSIL had CIN2 or higher, suggesting that the practice of referral for colposcopy should continue. |
| Databáze: | OpenAIRE |
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