Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review
| Autor: | Yong-Ya Ren, Jing Wang, Tianqin Wu, Zhaoyue Wang, Hai-Fei Chen, Qing-Ya Cui, Jie-Qing Tang, Zhi-Yong Luo, Li-Ping Xu, Ke-Yuan Wang, Ling-Juan Jin, Long-Mei Qin, Hongshi Shen, Zheng-Yang Li, Ziqiang Yu, Jing-Jing Zhu |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Time Factors side effect Side effect Hearing loss cerebellopontine angle hypofibrinogenemia Pharmaceutical Science Review Seizures Drug Discovery Humans Medicine Pathological Pharmacology cerebral hemorrhage Valproic Acid medicine.diagnostic_test Afibrinogenemia business.industry Magnetic resonance imaging Hypofibrinogenemia Cerebellopontine angle Anesthesia Anticonvulsants lipids (amino acids peptides and proteins) medicine.symptom business neoplasm medicine.drug |
| Zdroj: | Drug Design, Development and Therapy |
| ISSN: | 1177-8881 |
| DOI: | 10.2147/dddt.s47718 |
| Popis: | A 41-year-old male had suffered from gradual hearing loss in his right ear for 2 years. Head computed tomography and magnetic resonance imaging scans showed a neoplasm in the cerebellopontine angle region, which was confirmed by the diagnosis of acoustic neurilemmoma by pathological findings after surgery. Following surgery, he routinely received valproic acid (VPA) to prevent seizures. However, the patient presented with hypofibrinogenemia and cerebral hemorrhage after taking VPA for 12 days. The hypofibrinogenemia recurred when VPA was re-administered. After withdrawal of VPA, his fibrinogen concentration rose to normal within several days. As far as we are aware, this is the first case of cerebral hemorrhage due to VPA to have been reported. Herein, as well as reporting on this case, a mini review of the relevant literature is also presented. |
| Databáze: | OpenAIRE |
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