White matter density is increased in patients with hypothalamic hamartoma and multiple seizure types
| Autor: | Travis Losey, John F. Kerrigan, Leslie C. Baxter, Yu-Tze Ng, Scott C. Beeman |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Hamartoma Epileptogenesis White matter Epilepsy Hypothalamic hamartoma Seizures Gelastic seizure Cerebellum Convulsion medicine Humans Age of Onset Child business.industry Seizure types Brain medicine.disease Magnetic Resonance Imaging Temporal Lobe medicine.anatomical_structure Neurology Child Preschool Female Neurology (clinical) Epilepsies Partial medicine.symptom Hypothalamic Neoplasms business Neuroscience |
| Zdroj: | Epilepsy research. 93(2-3) |
| ISSN: | 1872-6844 |
| Popis: | Summary Many patients with hypothalamic hamartomas present in infancy with gelastic seizures of subcortical origin, but later develop additional seizure types, including complex partial, tonic, and generalized tonic–clonic seizures. The basic cellular mechanisms responsible for this evolution in seizure types are unknown. Using voxel-based morphometry of T1 weighted MRI scans we compared eight patients with only gelastic seizures with 16 age-matched patients with multiple seizure types and found significantly greater white matter density in the temporal lobes and cerebellum in those with multiple seizure types. This suggests that increased white matter density, perhaps resulting from maturational changes and resulting in increased brain connectivity, is associated with a higher likelihood of cortical involvement in epilepsy resulting from hypothalamic hamartoma. |
| Databáze: | OpenAIRE |
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