Early history of circular RNAs, children of splicing
| Autor: | Mariano A. Garcia-Blanco, Zvi Pasman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Spliceosome RNA Splicing Computational biology Biology History 21st Century 03 medical and health sciences Exon Circular RNA RNA Precursors Humans Small nucleolar RNA Molecular Biology Genetics Intron RNA Cell Biology Exons RNA Circular History 20th Century Long non-coding RNA Introns 030104 developmental biology Eukaryotic Cells Point of Views RNA splicing Spliceosomes Nucleic Acid Conformation RNA Splice Sites |
| Zdroj: | RNA biology. 14(8) |
| ISSN: | 1555-8584 |
| Popis: | In this commentary we briefly summarize early work on circular RNAs derived from spliceosome mediated circularization. We highlight how this early work inspired work on the basic mechanisms of nuclear RNA splicing, the possible function of circular RNAs and the potential uses of circular RNAs as tools in biomedicine. Recent developments in the study of circular RNAs, summarized in this volume, have brought these questions back to the foreground. |
| Databáze: | OpenAIRE |
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