The FMRP regulon: From targets to disease convergence
Autor: | Esperanza Fernández, Nicholas Rajan Rajan, Claudia Bagni |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
congenital
hereditary and neonatal diseases and abnormalities autism RNA-binding protein RNA-binding proteins Biology lcsh:RC321-571 Transcriptome Mini Review Article medicine Genetics local protein synthesis fragile X syndrome Gene lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Messenger RNA synaptic plasticity major depressive disorders General Neuroscience Settore BIO/13 medicine.disease nervous system diseases Fragile X syndrome schizophrenia FMRP Regulon Synaptic plasticity Autism RNA binding proteins Neuroscience |
Zdroj: | Frontiers in Neuroscience Frontiers in Neuroscience, Vol 7 (2013) |
Popis: | The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in 1991, many studies have primarily focused on understanding the function/s of this protein. Hundreds of potential FMRP mRNA targets and several interacting proteins have been identified. Here, we report the identification of FMRP mRNA targets in the mammalian brain that support the key role of this protein during brain development and in regulating synaptic plasticity. We compared the genes from databases and genome-wide association studies with the brain FMRP transcriptome, and identified several FMRP mRNA targets associated with autism spectrum disorders, mood disorders and schizophrenia, showing a potential common pathway/s for these apparently different disorders. ispartof: Frontiers in Neuroscience vol:7 issue:7 OCT pages:1-9 ispartof: location:Switzerland status: published |
Databáze: | OpenAIRE |
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