A Nitrate-Rich Vegetable Intervention Elevates Plasma Nitrate and Nitrite Concentrations and Reduces Blood Pressure in Healthy Young Adults
| Autor: | Jean Nyakayiru, Kristin L. Jonvik, Luc J. C. van Loon, Maria T. E. Hopman, Cindy M T van der Avoort, Lex B. Verdijk |
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| Přispěvatelé: | Humane Biologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male BEETROOT JUICE Blood Pressure Beetroot Juice Plant Roots chemistry.chemical_compound DOUBLE-BLIND 0302 clinical medicine Nitrate Vegetables/chemistry Vegetables Medicine Nitrite Young adult Nitrosamines/urine EXERCISE PERFORMANCE Nutrition and Dietetics Cross-Over Studies General Medicine INTENSITY EXERCISE Nitrates/administration & dosage young adult Female INORGANIC NITRATE Beta vulgaris ARTERIAL STIFFNESS Adult Nitrosamines Adolescent ENDOTHELIAL FUNCTION 030209 endocrinology & metabolism Nitrites/blood Blood Pressure/drug effects Nitric oxide Beverages 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center Animal science Dietary Nitrate Humans Nitrites 030109 nutrition & dietetics Nitrates business.industry Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6] Crossover study Cardiovascular health Dietary intervention Blood pressure chemistry TIME-TRIAL PERFORMANCE DIETARY NITRATE POSTPRANDIAL HYPOTENSION business diet Food Science |
| Zdroj: | Journal of the Academy of Nutrition and Dietetics, 120(8), 1305-1317. Elsevier Science Journal of the Academy of Nutrition and Dietetics Journal of the Academy of Nutrition and Dietetics, 120, 1305-1317 Journal of the Academy of Nutrition and Dietetics, 120, 8, pp. 1305-1317 |
| ISSN: | 2212-2672 |
| Popis: | Background Emerging evidence suggests that increasing dietary nitrate intake may be an effective approach to reduce blood pressure. Beetroot juice is often used to supplement dietary nitrate, whereas nitrate intake levels from habitual diet are low. An increase in the habitual intake of nitrate-rich vegetables may represent an alternative to nitrate supplementation. However, the effectiveness and acceptability of a nitrate–rich-vegetables diet remain to be established. Objective The aim was to investigate the effect and feasibility of two different intervention strategies to increase dietary nitrate intake, on plasma nitrate/nitrite concentrations and blood pressure. Design A randomized, crossover trial was used. Participants Participants were healthy men and women (both n=15; age: 24±6 years) from the Netherlands. Intervention Participants were instructed to consume ∼400 mg nitrate at lunch, provided through nitrate-rich vegetables and dietary counseling, or beetroot juice supplementation. Both interventions lasted 1 week, with 1-week washout (January to April 2017). Main outcome Plasma nitrate and nitrite concentrations and resting systolic and diastolic blood pressure were measured in an overnight fasted state (before and after intervention) and ∼2.5 hours after lunch (before and throughout intervention on day 1, 4, and 7). Statistical analysis Two-factor (time × treatment) repeated-measures analyses of variance were performed. Results Mean plasma nitrate concentrations increased with both interventions, with a larger increase in beetroot juice vs nitrate-rich vegetables, both in a fasted state and ∼2.5 hours after lunch (day 1, beetroot juice: 2.31±0.56 mg/dL [373±90 μmol/L] vs nitrate-rich vegetables: 1.71±0.83 mg/dL [277±134 μmol/L]; P |
| Databáze: | OpenAIRE |
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