Efficient Formal Total Synthesis of the Erythrina Alkaloid (+)-Erysotramidine, Using a Domino Process
| Autor: | Nina Tölle, Lutz F. Tietze, Dietmar Stalke, Daniel Kratzert |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Models
Molecular Molecular Structure 010405 organic chemistry Stereochemistry Chemistry Erysotramidine Organic Chemistry Total synthesis Iminium Stereoisomerism Electrophilic aromatic substitution Crystallography X-Ray 010402 general chemistry Amides Heterocyclic Compounds 4 or More Rings 01 natural sciences Biochemistry 0104 chemical sciences 3. Good health Erythrina alkaloid Cyclization Organic chemistry Domino process Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 11:5230-5233 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A domino process consisting of an amidation, spirocyclization, and formation of an iminium ion and electrophilic aromatic substitution of a phenylethylamine and a ketoester leads to the spirocyclic skeleton of (+)-erysotramidine, which can be further transformed into the natural alkaloid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|