Spiropyrans for light-controlled drug delivery
| Autor: | Silvia Giordani, Elisa Del Canto, Francesca Cardano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Spiropyran
Drug Carriers Ternary numeral system Indoles Aspirin Light 010405 organic chemistry Chemistry chemistry.chemical_element Zinc 010402 general chemistry Nitro Compounds Photochemical Processes 01 natural sciences Combinatorial chemistry 0104 chemical sciences Supramolecular assembly Inorganic Chemistry chemistry.chemical_compound Active compound Drug delivery Benzopyrans Derivative (chemistry) |
| Popis: | The supramolecular assembly of acetylsalicylic acid to a merocyanine-Zn complex translates into a photo-controllable drug delivery system. Herein, we present the synthesis and spectroscopic analysis of a three-component assembly combining a spiropyran derivative, a zinc(ii) cation, and acetylsalicylic acid. The ON/OFF system can be modulated by safe and easily affordable stimuli, for the specific delivery of more than one active compound. Our results confirm the formation of a ternary system in solution, where the behaviour is dominated by photo-induced responses, and pave the way for the use of such smart platforms for medicinal chemistry purposes. |
| Databáze: | OpenAIRE |
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