Dynamic changes of muscle insulin sensitivity after metabolic surgery
| Autor: | Klaus Strassburger, Sofiya Gancheva, Lucia Mastrototaro, Chrysi Koliaki, Markus Jähnert, Christian Herder, Daniel F. Markgraf, Matthias Schlensak, Dominik Pesta, Elisabetta De Filippo, Julia Szendroedi, Annette Schürmann, Jürgen Weiss, Frederico G.S. Toledo, Michael Roden, Meriem Ouni, Tomas Jelenik |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Science Gastric Bypass General Physics and Astronomy Adipose tissue 030209 endocrinology & metabolism Article General Biochemistry Genetics and Molecular Biology Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Insulin resistance Weight loss Internal medicine medicine ddc:61 Lipolysis Humans Epigenetics Obesity Muscle Skeletal lcsh:Science Multidisciplinary business.industry Skeletal muscle Lipid metabolism General Chemistry Metabolism DNA Methylation Middle Aged medicine.disease Lipid Metabolism 030104 developmental biology Endocrinology medicine.anatomical_structure Adipose Tissue Institut für Ernährungswissenschaft Female lcsh:Q medicine.symptom Insulin Resistance business |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity. Surgical weight-loss interventions improve insulin sensitivity via incompletely understood mechanisms. Here the authors assess skeletal muscle epigenetic changes in individuals with obesity following metabolic surgery and compare them with data from individuals without obesity. |
| Databáze: | OpenAIRE |
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