Genetic hazards of ionizing radiations: cytogenetic extrapolations from mouse to man
| Autor: | D.G. Gosslee, R.J. Preston, K.P. Jones, J.G. Brewen |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Swine
Health Toxicology and Mutagenesis Chromosomal translocation Biology Hybrid Cells Chromosomes Ionizing radiation Dicentric chromosome Mice Cricetinae Genetics Leukocytes Animals Humans Radiation Genetics Radiation Injuries Molecular Biology Chromosome Aberrations Chromosome Dose-Response Relationship Radiation Haplorhini Radiation Injuries Experimental Linear relationship Marsupialia Chromosome Arm |
| Zdroj: | Mutation research. 17(2) |
| ISSN: | 0027-5107 |
| Popis: | The frequencies of X-ray induced asymmetrical interchanges (dicentrics) and acentric fragments (deletions) at several doses were measured in the circullating leukocytes of six species. The leukocytes of the species used had similar DNA contents but different chromosome and chromosome arm numbers. The data for dicentrics were fitted separately for each species by regression analysis to the model Yj = bjD + cjD2. All species gave a good fit to this model. As expected, when the dicentric data for all species were pooled and fitted to this model a poor fit was obtained. However, if a term for arm number was included, so that the model Yj = (Nj−1) (bD+cD2) was fitted, a significant amount of the variation among species could be accounted for. At each dose there was an approximately linear relationship between the yield of dicentrics and the arm number. Man, with an effective arm number of 81, had twice as many dicentrics as the mouse, with an effective arm number of. These results strongly suggest that the chromosome arm number of a species influences the yield of asymmetrica interchanges. The chromosome arm number did not appear to influence the yield of deletions, and the yields induced in the mouse and man at easch dose were equal. These results show that man is twice as sensitive as the mouse to the induction of translocations, whereas the two species are equally sensitive to the indcution of deletions and, in all probability, to the production of mutations. |
| Databáze: | OpenAIRE |
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