Pancreatic ductal adenocarcinoma: Prognostic indicators of advanced disease

Autor: Deirdré Kruger, Nicola Lahoud, Yandiswa Y. Yako, John Devar, Martin Smith
Rok vydání: 2021
Předmět:
Male
endocrine system diseases
Epidemiology
Physiology
Biochemistry
Metastasis
Endocrinology
Medical Conditions
Risk Factors
Animal Cells
Basic Cancer Research
Medicine and Health Sciences
Prospective Studies
Multidisciplinary
Cancer Risk Factors
Middle Aged
Prognosis
Body Fluids
Blood
Oncology
Lymphatic Metastasis
Disease Progression
Medicine
Cytokines
Female
Anatomy
Cellular Types
Carcinoma
Pancreatic Ductal
Research Article
Platelets
Endocrine Disorders
Science
Adenocarcinoma
Pancreatic Cancer
Diagnostic Medicine
Gastrointestinal Tumors
Biomarkers
Tumor
Cancer Detection and Diagnosis
Diabetes Mellitus
Humans
Blood Cells
Biology and Life Sciences
Cancers and Neoplasms
Cell Biology
digestive system diseases
Pancreatic Neoplasms
Medical Risk Factors
Metabolic Disorders
Biomarkers
Follow-Up Studies
Zdroj: PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262439 (2022)
ISSN: 1932-6203
Popis: Background/Objectives Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy associated with high metastatic risk. Prognosis remains poor even after resection. Previously our group identified biomarkers that improved diagnostic accuracy in PDAC beyond the established diagnostic tumour marker, CA19-9. Risk factors, symptoms and circulating biomarkers associated with a PDAC diagnosis may differ from those that alter disease progression and metastasis. This study aimed at assessing the risk factors, presenting symptoms and potential prognostic biomarkers in PDAC and determine their relationship with PDAC stage and/or metastatic status. Methods Seventy-two PDAC patients with imaging available for TNM staging at presentation were enrolled following informed consent. Demographic and clinical data were captured. Blood was collected and 38 cytokines/angiogenic factors measured. Nonparametric association tests, univariate and multivariate logistic regression were performed using STATA version 14.2. A p-value≤0.05 was considered significant and odds ratios reported for effect size. Results Most risk factors and symptoms did not differ across the stages of cancer. Although male gender and smoking are risk factors for PDAC, the majority of study patients with metastatic PDAC were non-smoking females. In addition to CA19-9, the platelet count (p Conclusions Platelet count, IL-15 and GM-CSF are potential prognostic indicators of metastatic disease in PDAC patients from our local South African population.
Databáze: OpenAIRE
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