Fluorescent in situ hybridization as a screening test for HER2 amplification inG2 and G3 breast cancers of lobular and ductal histotype and metastases
| Autor: | Antonio Marchetti, Gianpaolo Trentini, Luigi Giusto Spagnoli, Isabella Castellano, Cesare Bordi, Paolo Tricomi, Alfredo Santinelli, Alessandra Bersiga, Massimo Roncalli, Giuseppe Viale, Francesco Tanda, Claudio Doglioni, Oscar Nappi, Francesco Romeo, Gaetano Barresi, Gianni Bussolati, Emanuele D'Amore, Roberto Bandelloni, Anna Sapino, R Arisio, Fabrizio Zanconati, Gerardo Botti, Monica Iurlaro, Rosa Russo, Fabia Cosimi |
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| Přispěvatelé: | Castellano, I, Sapino, A, Arisio, R, Viale, G, Bussolati, G, Bandelloni, R, Barresi, G, Bersiga, A, Bordi, C, Botti, G, Cosimi, F, D'Amore, E, Doglioni, C, Marchetti, A, Nappi, O, Romeo, F, Roncalli, M, Russo, R, Santinelli, A, Spagnoli, Lg, Tanda, F, Tricomi, P, Trentini, G, Zanconati, Fabrizio, Iurlaro, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
FISH
HER2 Histotype breast grade Cancer Research Pathology Time Factors Lymphovascular invasion Receptor ErbB-2 Mammary gland Medical Oncology Metastasis Models Mass Screening Neoplasm Metastasis skin and connective tissue diseases In Situ Hybridization In Situ Hybridization Fluorescence fluorescence in situ hybridisation medicine.diagnostic_test General Medicine Statistical medicine.anatomical_structure Oncology Hormone receptor Female Receptor medicine.medical_specialty effectiveness In situ hybridization Biology Settore MED/08 - Anatomia Patologica Fluorescence Breast cancer medicine Humans cancer Neoplasm Invasiveness metastases neoplasms erbB-2 Neoplasm Staging Models Statistical Cancer Reproducibility of Results Genes erbB-2 medicine.disease body regions Receptor erbB-2 Multivariate Analysis Genes effectivene Fluorescence in situ hybridization |
| Zdroj: | Scopus-Elsevier |
| Popis: | The aim of the present study was to evaluate the effectiveness of fluorescence in situ hybridisation (FISH), as a screening test, in moderately- (G2) or poorly- (G3) differentiated breast cancers of the ductal (IDC) and lobular (ILC) histotypes and distant metastases. HER2 FISH was performed on 486 G2 and 477 G3 both of IDC and ILC histotypes and in 241 metastases. A significant difference in the HER2 amplification was observed between G2 (14.8%) and G3 (31.9%), with no difference according to the histotype. However, the rate of amplification increased to 36% in the G2/hormone receptor-negative cases as compared to 10.6% in the G2/receptor-positive cases (p |
| Databáze: | OpenAIRE |
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