Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer's disease and other dementias
| Autor: | Guillaume Vicat, Sandra Cobo, Jean-Daniel Abraham, Nicolas Salvetat, Jacques Touchon, Laurence Molina, Sophie Calvayrac-Pawlowski, Bernard-François Michel, Jeannette Fareh, Jean-Michel Verdier, Chantal Mourton-Gilles, Franck Molina |
|---|---|
| Přispěvatelé: | Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Proteomics MILD COGNITIVE IMPAIRMENT Health Toxicology and Mutagenesis [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Clinical Biochemistry Pilot Projects medicine.disease_cause Biochemistry Severity of Illness Index 0302 clinical medicine Cerebrospinal fluid MARKERS Neurotrophic factors OPERATING CHARACTERISTIC CURVES ROC OXIDATIVE STRESS Aged 80 and over 0303 health sciences biology Haptoglobin Middle Aged Frontotemporal Dementia Biomarker (medicine) Female DIFFERENTIAL-DIAGNOSIS Oxidation-Reduction PHOSPHORYLATED-TAU Molecular Sequence Data EPITHELIUM-DERIVED FACTOR Enzyme-Linked Immunosorbent Assay tau Proteins CELL-LINES CSF Antibodies Diagnosis Differential 03 medical and health sciences PEDF Alzheimer Disease medicine Dementia Humans Amino Acid Sequence Nerve Growth Factors Eye Proteins Serpins 030304 developmental biology Aged Haptoglobins business.industry Dementia Vascular Biomarker medicine.disease Cognitive Test Immunology biology.protein Differential diagnosis business 030217 neurology & neurosurgery Oxidative stress Biomarkers Neurological disease NEUROTROPHIC FACTOR |
| Zdroj: | Convergence Convergence, SAGE Publications, 2011, 16 (2), pp.161-71. ⟨10.3109/1354750X.2010.536995⟩ |
| ISSN: | 1354-8565 |
| DOI: | 10.3109/1354750X.2010.536995⟩ |
| Popis: | International audience; Using proteomic approach in cerebrospinal fluid (CSF) we identified pigment epithelium-derived factor (PEDF) and Haptoglobin (Hp) as putative markers that could discriminate between AD and other dementias. ELISA assays were developed to measure the levels of PEDF and Hp in CSF from patients with AD (AD, n=27), non-AD (NAD, n=30) and in non-demented patients (ND, n=27). The combined assessment of PEDF, Hp and Tau levels, using Iterative Marginal Optimization, improved the differential diagnosis of AD, especially in patients with moderate to severe dementia (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|