Impairment of splenic natural killer cell activity of mice infected with the polycythemic strain of friend leukemia virus

Autor:	Enzo Bonmassar, T Jezzi, Graziella Migliorati, Giovanni Rossi, Cartesio Favalli, Enrico Garaci
Rok vydání:	1982
Předmět:	Cancer Research Lymphokine-activated killer cell Effector Immunology Spleen Biology Natural killer T cell Virology Virus Cytolysis medicine.anatomical_structure Oncology Antigen Splenocyte medicine Immunology and Allergy
Zdroj:	Cancer Immunology Immunotherapy. 12
ISSN:	1432-0851 0340-7004
DOI:	10.1007/bf00205378
Popis:	The natural killer (NK) cell activity of DBA/2J mice infected with the polycythemic variant of Friend leukemia virus (FLV-P) declines early after virus challenge, being non-detectable 2 weeks after FLV-P inoculation. Cells capable of suppressing the in vitro cytolytic activity of NK effector lymphocytes were detected in the spleen of infected mice. The mechanism of suppression could be based on cell-mediated impairment of NK effector function, or on antigenic competition from splenocytes expressing NK antigens elicited by FLV-P.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301c441cc1496cab8a5b3886f8145c48 https://doi.org/10.1007/bf00205378 Zobrazit plný text záznamu Full text from SpringerLink