Nopol-Based Quinoline Derivatives as Antiplasmodial Agents
| Autor: | Jasmine T. Collins, Huaisheng Zhang, Ifedayo Victor Ogungbe, Olamide Crown, Rogers Nyamwihura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Plasmodium
South asia Primaquine Plasmodium falciparum Plasmodium vivax malaria Pharmaceutical Science Pharmacology Article Analytical Chemistry Aminoquinoline lcsh:QD241-441 Antimalarials Bridged Bicyclo Compounds 03 medical and health sciences chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery parasitic diseases medicine Gametocyte Humans Physical and Theoretical Chemistry 030304 developmental biology 0303 health sciences biology 030306 microbiology Organic Chemistry Quinoline Hep G2 Cells aminoquinoline biology.organism_classification medicine.disease chemistry nopol Chemistry (miscellaneous) α-pinene Quinolines Molecular Medicine Malaria medicine.drug |
| Zdroj: | Molecules, Vol 26, Iss 1008, p 1008 (2021) Molecules Volume 26 Issue 4 |
| ISSN: | 1420-3049 |
| Popis: | Malaria remains a significant cause of morbidity and mortality in Sub-Saharan Africa and South Asia. While clinical antimalarials are efficacious when administered according to local guidelines, resistance to every class of antimalarials is a persistent problem. There is a constant need for new antimalarial therapeutics that complement parasite control strategies to combat malaria, especially in the tropics. In this work, nopol-based quinoline derivatives were investigated for their inhibitory activity against Plasmodium falciparum, one of the parasites that cause malaria. The nopyl-quinolin-8-yl amides (2–4) were moderately active against the asexual blood stage of chloroquine-sensitive strain Pf3D7 but inactive against chloroquine-resistant strains PfK1 and PfNF54. The nopyl-quinolin-4-yl amides and nopyl-quinolin-4-yl-acetates analogs were generally less active on all three strains. Interesting, the presence of a chloro substituent at C7 of the quinoline ring of amide 8 resulted in sub-micromolar EC50 in the PfK1 strain. However, 8 was more than two orders of magnitude less active against Pf3D7 and PfNF54. Overall, the nopyl-quinolin-8-yl amides appear to share similar antimalarial profile (asexual blood-stage) with previously reported 8-aminoquinolines like primaquine. Future work will focus on investigating the moderately active and selective nopyl-quinolin-8-yl amides on the gametocyte or liver stages of Plasmodium falciparum and Plasmodium vivax. |
| Databáze: | OpenAIRE |
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