Acute toxicity studies, physicochemical and GC/MS analyses of Monodora myristica (Gaertn.) Dunal oil
| Autor: | Miediegha, O., Owaba, A.D.C., Okori-West, L. |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Nigerian Journal of Pharmaceutical Research; Vol. 18 No. 2 (2022); 91-99 |
| ISSN: | 2635-3555 0189-8434 |
| DOI: | 10.4314/njpr.v18i2.1 |
| Popis: | Background: The seeds of Monodora myristica, a tropical plant belonging to the family Annonaceae, are widely used as condiments in the preparation of a number of African delicacies, to impart or enhance flavour. Their use is largely due to the volatile and fixed oils contained in the nuts.Objective: To screen for the acute toxicity (LD50) profile, determine the physicochemical properties, as well as carry out GC-MS analysis of the seed oil of Monodora myristica.Method: The acute toxicity screening was done using Lorke’s method. Physicochemical profile of the oil was determined using standard methods. GC-MS analysis of the oil sample was also carried out, using Shimadzu GCMS-QP2010SE.Results: The acute toxicity study showed that the oil sample had an LD50 of 316 mg/kg. The acid value was determined to be 9.27 mg KOH/g oil, while saponification value was 194.95 mg KOH/g oil. GC-MS analysis of the oil revealed that it contained fatty acids such as n-hexadecanoic acid, cis-vaccenic acid and 9,12-octadecadienoic acid; as well as terpinoids such as alpha-terpineol and alpha-cadinol.Conclusion: Results of the toxicological screening indicates that Monodora myristica oil is moderately toxic as the LD50 was within 50 – 500 mg/kg range. The oil has a relatively high tendency to go rancid due to the high acid value of 9.27 mg KOH/g oil. |
| Databáze: | OpenAIRE |
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