Metal-free imidazolium salts inhibit the growth of hepatocellular carcinoma in a mouse model
| Autor: | Nur-Afidah Mohamed Suhaimi, Chunyan Zhang, Siti Nurhanna Riduan, Began Gopalan, Lang Zhuo, Yinling Kng, Yugen Zhang, Zhiyuan Ke |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Carcinoma Hepatocellular Survivin Blotting Western Mice Nude Biology Inhibitor of Apoptosis Proteins Pathology and Forensic Medicine Mice Liver Neoplasms Experimental In vivo Internal medicine In Situ Nick-End Labeling medicine Animals Molecular Biology Mice Inbred BALB C Cell growth Cell Cycle Imidazoles Cell Biology Cell cycle medicine.disease Immunohistochemistry Cyclin-Dependent Kinases Repressor Proteins Disease Models Animal Endocrinology Apoptosis Hepatocellular carcinoma Toxicity Cancer research Salts Liver cancer Cell Division |
| Zdroj: | Laboratory Investigation. 91:744-751 |
| ISSN: | 0023-6837 |
| DOI: | 10.1038/labinvest.2011.4 |
| Popis: | Imidazolium salts (IMSs) are precursors to N-heterocyclic carbenes (NHCs), which are routinely used as ligands or organo-catalysts in synthetic chemistry. We recently identified several IMSs as anti-fibrotic agents in liver fibrosis, which often has a consequence in the oncogenesis of hepatocellular carcinoma (HCC). Here, we investigate the potential anti-tumor property of three IMSs (named IBN-1, IBN-9, and DPIM) in HCC cell lines and in a xenograft mouse model. Our results showed that both IBN-1 and IBN-9 significantly inhibited the cell proliferation and arrested HCC cells in the G1-phase, whereas DPIM did not have any anti-tumor activity. When tested in a Huh7 HCC xenograft mouse model, IBN-1 reduced the tumor volume by 31% (P |
| Databáze: | OpenAIRE |
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