Developmental Changes in the ECG of a Hamster Model of Muscular Dystrophy and Heart Failure
| Autor: | Thomas G. Hampton, Case G. VanDongen, Scott McCue, Hemmi N. Bhagavan, Ajit Kale |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
muscular dystrophy
medicine.medical_specialty Genetic enhancement Cardiomyopathy Hamster Review Article Autonomic Nervous System Internal medicine δ-sarcoglycan deficiency Heart rate Medicine Heart rate variability Pharmacology (medical) Muscular dystrophy development BIO TO-2 hamsters Heart Failure Pharmacology delta-sarcoglycan deficiency business.industry lcsh:RM1-950 hamsters medicine.disease Autonomic nervous system lcsh:Therapeutics. Pharmacology Endocrinology Heart failure business cardiomyopathy |
| Zdroj: | Frontiers in Pharmacology, Vol 3 (2012) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2012.00080 |
| Popis: | Aberrant autonomic signaling is being increasingly recognized as an important symptom in neuromuscular disorders. The delta-sarcoglycan-deficient BIO TO-2 hamster is recognized as a good model for studying mechanistic pathways and sequelae in muscular dystrophy and heart failure, including autonomic nervous system dysfunction. Recent studies using the TO-2 hamster model have provided promising preclinical results demonstrating the efficacy of gene therapy to treat skeletal muscle weakness and heart failure. Methods to accelerate preclinical testing of gene therapy and new drugs for neuromuscular diseases are urgently needed. The purpose of this investigation was to demonstrate a rapid non-invasive screen for characterizing the autonomic nervous system imbalance in dystrophic TO-2 hamsters. Electrocardiograms were recorded non-invasively in conscious ~9-month old TO-2 hamsters (n=10) and non-myopathic F1B control hamsters (n=10). Heart rate was higher in TO-2 hamsters than controls (453 ± 12 bpm vs. 311 ± 25 bpm, P |
| Databáze: | OpenAIRE |
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