Progressive multifocal leukoencephalopathy and granule cell neuronopathy with novel mutation flanking VP1 C-terminus in natalizumab-extended interval dosing
| Autor: | Augusto Miravalle, Yang Mao-Draayer, Torge Rempe, Zachary Newcomer, Qin Wang, Qi Wu, Varalakshmi Ballur Narayana Reddy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
viruses
medicine.disease_cause Virus 03 medical and health sciences Multiple Sclerosis Relapsing-Remitting 0302 clinical medicine Natalizumab Cerebellar Diseases Humans Immunologic Factors Medicine 030212 general & internal medicine Clinical/Scientific Notes Aged Mutation business.industry C-terminus Progressive multifocal leukoencephalopathy Leukoencephalopathy Progressive Multifocal virus diseases Granule cell medicine.disease JC Virus Virology medicine.anatomical_structure Neurology Capsid Capsid Proteins Female Neurology (clinical) business Novel mutation 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurology® Neuroimmunology & Neuroinflammation |
| ISSN: | 2332-7812 |
| Popis: | Reactivation of a dormant infection with the John Cunningham virus (JCV) can lead to the rare neurologic disorders progressive multifocal leukoencephalopathy (PML) and granule cell neuronopathy (GCN), a cerebellar syndrome with progressing cerebellar atrophy.1 Here, we present a case of infratentorial PML with concomitant GCN in extended interval dosing (EID) of natalizumab associated with a novel mutation at 7th position after the C-terminus of viral capsid protein VP1 in addition to the common noncoding regulatory region (NCRR) mutation. |
| Databáze: | OpenAIRE |
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