Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality
| Autor: | Gillian Libby, F A Carey, Robert Steele, Callum G. Fraser, David H. Brewster |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer Population Risk Assessment 03 medical and health sciences 0302 clinical medicine Cause of Death Internal medicine medicine Humans Mortality education Early Detection of Cancer Feces Aged Cause of death Cancer mortality education.field_of_study business.industry Gastroenterology Middle Aged medicine.disease Occult Drug Utilization Non colorectal Databases as Topic Scotland Occult Blood 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Medical Record Linkage Colorectal Neoplasms Gastrointestinal Hemorrhage business All cause mortality |
| ISSN: | 0017-5749 |
| Popis: | ObjectiveAn association between detectable faecal haemoglobin (f-Hb) and both the risk of death from colorectal cancer (CRC) and all-cause mortality has been reported. We set out to confirm or refute this observation in a UK population and to explore the association between f-Hb, as indicated by a positive guaiac faecal occult blood test (gFOBT) result, and different causes of death.DesignAll individuals (134 192) who participated in gFOBT screening in Tayside, Scotland between 29/03/2000 and 29/03/2016 were studied by linking their test result (positive or negative) with mortality data from the National Records of Scotland database and following to 30/03/2016.ResultsThose with a positive test result (n=2714) had a higher risk of dying than those with a negative result, from CRC: HR 7.79 (95% CI 6.13 to 9.89), pConclusionThe presence of detectable f-Hb is associated with increased risk of death from a wide range of causes. |
| Databáze: | OpenAIRE |
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