Newborn Rats in the Murine Typhus Enzootic Infection Cycle: Studies on Transplacental Infection and Passively Acquired Maternal Antirickettsial Antibodies
| Autor: | Abdu F. Azad, Arango-Jaramillo S, Wisseman Cl |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Offspring
Murine typhus Rodent Diseases Mice Pregnancy Virology Rickettsia typhi Animals Medicine Pregnancy Complications Infectious Maternal-Fetal Exchange Fetus biology business.industry Colostrum Antibody titer Transplacental Rats Inbred Strains Typhus Endemic Flea-Borne biology.organism_classification medicine.disease Antibodies Bacterial Rats Titer Milk Infectious Diseases Animals Newborn Immunology Female Parasitology business Immunity Maternally-Acquired |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 39:391-397 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1988.39.391 |
| Popis: | This study focused attention on the newborn rat as a possible significant participant in the highly successful enzootic cycle of murine typhus. We examined the influence of maternal Rickettsia typhi (R. mooseri) infection in rats on the offspring with respect to the possible vertical transmission of R. typhi and the passive transfer of maternal antirickettsial antibodies. Transmission of R. typhi by rickettsemic pregnant rats did not occur either transplacentally during gestation to their fetuses or postnatally through colostrum and milk to their newborn. The rickettsial burden of the placenta was sometimes greater than 10(6) plaque forming units per g tissue and undetectable in colostrum or milk. However, newborn rats were highly susceptible to infection per os. Transplacental passage of antirickettsial antibody to offspring was detectable only when the mother's antibody titer was high. Passive postpartum acquisition of antirickettsial antibodies by newborn rats from colostrum and milk of immune mothers occurred regardless of the height of the maternal antibody titer, rose to a maximum at about 3 weeks of age, and then declined rapidly, becoming undetectable 4 weeks after birth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|