Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model

Autor: José Alexandre de Souza Crippa, G.H. Callejas, Rebeca Lopes Figueira, Lourenço Sbragia, Jaime Eduardo Cecílio Hallak, Antonio Waldo Zuardi, F.A.P. Volpe, Frances Lilian Lanhellas Gonçalves
Rok vydání: 2018
Předmět:
Antioxidant
Physiology
medicine.medical_treatment
Anti-Inflammatory Agents
Nitric Oxide Synthase Type II
Biochemistry
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Cannabidiol
General Pharmacology
Toxicology and Pharmaceutics
Nitrite
lcsh:QH301-705.5
Research Articles
Gastroschisis
lcsh:R5-920
Chemistry
General Neuroscience
General Medicine
Immunohistochemistry
Enteritis
Prenatal treatment
Intestines
Fetal Diseases
030220 oncology & carcinogenesis
Gestation
Female
lcsh:Medicine (General)
medicine.drug
medicine.medical_specialty
DIAGNÓSTICO PRÉ-NATAL
medicine.drug_class
Immunology
Biophysics
Ocean Engineering
Anti-inflammatory
03 medical and health sciences
Internal medicine
medicine
Animals
Experimental model
Nitrites
Fetus
Nitrates
Abdominal wall defect
Cell Biology
medicine.disease
Rats
Disease Models
Animal
Endocrinology
lcsh:Biology (General)
030217 neurology & neurosurgery
Zdroj: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research, Vol 51, Iss 5 (2018)
Brazilian Journal of Medical and Biological Research, Volume: 51, Issue: 5, Article number: e7132, Published: 15 MAR 2018
Brazilian Journal of Medical and Biological Research v.51 n.5 2018
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Popis: Gastroschisis (GS) is an abdominal wall defect that results in histological and morphological changes leading to intestinal motility perturbation and impaired absorption of nutrients. Due to its anti-inflammatory, antioxidant, and neuroprotective effects, cannabidiol (CBD) has been used as a therapeutic agent in many diseases. Our aim was to test the effect of maternal CBD in the intestine of an experimental model of GS. Pregnant rats were treated over 3 days with CBD (30 mg/kg) after the surgical induction of GS (day 18.5 of gestation) and compared to controls. Fetuses were divided into 4 groups: 1) control (C); 2) C+CBD (CCBD); 3) gastroschisis (G), and 4) G+CBD (GCBD). On day 21.5 of gestation, the fetuses were harvested and evaluated for: a) body weight (BW), intestinal weight (IW), and IW/BW ratio; b) histometric analysis of the intestinal wall; c) immunohistochemically analysis of inflammation (iNOS) and nitrite/nitrate level. BW: GCBD was lower than CCBD (P
Databáze: OpenAIRE
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