Microglia/monocytes with NG2 expression have no phagocytic function in the cortex after LPS focal injection into the rat brain
| Autor: | Samuel Sam Wah Tay, Lie Zhu, Hua Jiang, Ping Xiang, Anni Wang, Kun Guo, Jia Lu, Bei Ping He |
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| Rok vydání: | 2012 |
| Předmět: |
Lipopolysaccharides
Male Lipopolysaccharide Phagocytosis Monocytes Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound medicine Animals Antigens Latex beads biology Microglia Brain Rats Cortex (botany) Cell biology medicine.anatomical_structure nervous system Neurology chemistry Chondroitin sulfate proteoglycan Immunology biology.protein Proteoglycans Antibody Function (biology) |
| Zdroj: | Glia. 60:1417-1426 |
| ISSN: | 0894-1491 |
| Popis: | While OX42(+) microglia/macrophages have been considered as a scavenger in the brain, NG2(+) cells are generally considered as oligodendrocyte progenitor cells or function-unknown glial cells. Recent evidence showed that under some pathological conditions, certain cells have become positive for both anti-NG2 and anti-OX42 antibodies. Our results suggested that some OX42(+) microglia or macrophages were induced to express NG2 proteins 3 and 5 days later after focal injection of lipopolysaccharide into the brain cortex of Sprague-Dawley rats. In consideration of the induction of NG2 expression may associate with gaining or losing functions of microglia/macrophages, we further showed that, while OX42(+) or ED1(+) microglia/macrophages presented active phagocytic function, NG2(+) /OX42(+) cells failed to engulf latex beads. The induced expression of NG2 protein may possibly indicate the functional diversity of activated microglia/macrophages in the brain. |
| Databáze: | OpenAIRE |
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