Early Retinal Findings Following Cooling in Neonatal Encephalopathy
Autor: | Mustafa Ali Akin, Ozlem Sahin, Nicola J. Robertson, Ender Sirakaya, Murat Cansever |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male 030105 genetics & heredity Electroencephalography Retina Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Brain Diseases medicine.diagnostic_test Ophthalmoscopic examination business.industry Retinal damage Neonatal encephalopathy Infant Newborn Magnetic resonance imaging Retinal General Medicine medicine.disease Magnetic Resonance Imaging Cross-Sectional Studies chemistry Cryotherapy Anesthesia Pediatrics Perinatology and Child Health Vitreous hemorrhage Hypoxia-Ischemia Brain Female Neurology (clinical) business 030217 neurology & neurosurgery Cohort study |
Zdroj: | Neuropediatrics. 50(1) |
ISSN: | 1439-1899 |
Popis: | Background and Aim Perinatal HI (hypoxia–ischemia)-related visual defects including blindness are known to be associated with ischemic lesions in intracerebral visual pathways and ischemic retinal damage (IRD). Intraocular hemorrhages (IOH) such as retinal hemorrhage (RH), which may result from perinatal HI, can cause IRD by various mechanisms. We aimed to evaluate the early retinal findings in neonates with moderate-to-severe neonatal encephalopathy (NE) who underwent TH and its relationship between coagulation status, amplitude-integrated electroencephalography (aEEG) patterns, and magnetic resonance imaging–magnetic resonance spectroscopy (MRI–MRS) findings. Method and Patients A total of 31 newborn infants who underwent moderate-to-severe NE and TH included in the study. Coagulation parameters were taken immediately before starting TH, and daily during TH period. aEEG records were obtained during TH and rewarming period.Binocular indirect ophthalmoscopic examination (BIOE) and MRI–MRS scanning were performed when TH protocol completed. Results Total 13 (41.9%) patients had abnormal BIOE findings. Ten of them were (77%) IOH, other findings are as follows: RH (n = 7), optic disc hemorrhage (n = 2), and vitreous hemorrhage (n = 1). Initial coagulation status was not related to IOH. Worsened aEEG and MRI–MRS results were not related to BIOE findings. Conclusion Frequency of IOH is high in newborns with NE who underwent TH being independent from severity of MRS–MRI findings, aEEG pattern, and disturbed coagulation status. |
Databáze: | OpenAIRE |
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