N-Ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat
Autor: | Hiroaki Mitani, Makoto Miyagawa, Okio Hino, Nobuo Satake, Toshiyuki Kobayashi, Junko Sakurai, Hiroshi Tamura |
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Rok vydání: | 2002 |
Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Tumor suppressor gene Biology Gene Mutant medicine.disease_cause Animals Genetically Modified In vivo Internal medicine Tuberous Sclerosis Complex 2 Protein Gene expression medicine Animals Humans Diethylnitrosamine Genes Tumor Suppressor Rats Wistar Carcinogen Regulation of gene expression Sex Characteristics Kidney Tumor Suppressor Proteins Liver Neoplasms Molecular biology Kidney Neoplasms Rats Repressor Proteins Endocrinology medicine.anatomical_structure Gene Expression Regulation Oncology Carcinogens Female Carcinogenesis |
Zdroj: | Cancer Letters. 184:157-163 |
ISSN: | 0304-3835 |
Popis: | Hereditary renal carcinomas (RCs) develop in Tsc2 gene mutant (Eker) rats around the age of 1 year. We previously reported that Tsc2 mutations were detected in chemically (N-ethyl-N-hydroxyethylnitrosamine (EHEN) and diethylnitrosamine)-induced non-Eker rat RCs, suggesting an involvement of Tsc2 alteration in rat RC development. In this study, we evaluated the effect of extra copies of the Tsc2 gene on renal and hepatocarcinogenesis that was induced by EHEN in vivo. The incidence of RCs in non-transgenic rats (2/17) is slightly higher than in transgenic rats (0/32), although it is statistically not significant. These results suggest the presence of other target RC gene(s) in chemically (EHEN)-induced renal carcinogenesis. We observed no difference in the numbers and areas of the hepatic glutathione S-transferase placental type positive foci. |
Databáze: | OpenAIRE |
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