Analyses on Possible Heterogeneity of Iddm Based on Presence of Islet Cell Cytoplasmic Antibody at Diagnosis
| Autor: | Allan L. Drash, Trevor J. Orchard, Bruce S. Rabin, Druie E. Cavender, Dorothy J. Becker, Robert W. Atchison, Mark S. Eberhardt, Ronald E. LaPorte, D K Wagener, Janice S. Dorman |
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| Rok vydání: | 1989 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent Epidemiologic Factors medicine.medical_treatment Immunology Cell Immunogenetics Biology Islets of Langerhans HLA Antigens Diabetes mellitus Internal medicine medicine Humans Immunology and Allergy Family history Child Autoantibodies geography geography.geographical_feature_category Insulin Age Factors Antibody titer Infant medicine.disease Islet Phenotype Diabetes Mellitus Type 1 Endocrinology medicine.anatomical_structure Child Preschool Multivariate Analysis cardiovascular system Female |
| Zdroj: | Autoimmunity. 2:113-122 |
| ISSN: | 1607-842X 0891-6934 |
| DOI: | 10.3109/08916938909019948 |
| Popis: | In a large, representative sample of newly-diagnosed IDDM patients, using a highly sensitive assay to detect islet cell cytoplasmic antibodies (ICA), no marked differences were found between ICA+ and ICA- patients on various clinical, genetic, immunologic, and epidemiologic characteristics. In particular, there was no evidence for associations between ICA status at diagnosis and either sex, race, family history of IDDM, HLA-DR phenotype, antibody titers to Coxsackie B viruses, immunoglobulin levels, C-peptide and glycosylated hemoglobin concentrations, or insulin requirements. The most significant relationship was between the presence of ICA and a young age at diagnosis; however, the large overlap between the distributions of the ages at onset for ICA+ and ICA- groups on this variable suggests that this association is of limited importance. These data suggest that the presence or absence of ICA at diagnosis may not be useful in defining possible subtypes of IDDM. |
| Databáze: | OpenAIRE |
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